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KMID : 0359319930330040617
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Korean Journal of Veterinary Research
1993 Volume.33 No. 4 p.617 ~ p.622
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Localization of adrenergic receptors in bovine esophageal groove
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Abstract
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The preliminary studies on the localization of adrenoceptors were performed bn smooth muscle strips of bovine esophageal groove. The mechanical activity of the muscle staps was recorded isometrically in vitro.
In the bottom circular muscle strips. the excitatory α-adrenergic responses were not blocked by tetrodotoxin(2.1×10^(-6)M) and denervation which was carried by cold storage of strips for 48 hrs an Tyrode´s solution at 5-6℃ without oxygen supply. These excitatory α-adrenergic responses were partially blocked by atropine. In the lip longitudinal muscle strips, the inhibitory (β-adrenergic responses were not blocked by pretreatment of tetrodotoxin and atropine.
The results suggest that β-adrenergic receptors mediating relaxations are located on the postsynaptic smooth muscle cells, whereas (β-adrenergic receptors mediating contractions are located both in the smooth muscle cells and in the cholinergic neurones.
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